Baking Soda. Because of its surprising effectiveness, baking soda is considered by many as one of the best treatments for herpes. Baking soda works by relieving the symptoms caused by herpes: it can reduce pain and itchiness. To use baking soda, add a tablespoon of baking soda with a few drops of water. Form a paste, and apply it onto the affected areas for a few minutes. Wash with warm water.